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Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy / by Matthias J.N.Junk
(Springer Theses, Recognizing Outstanding Ph.D. Research. ISSN:21905053)
| データ種別 | 電子ブック |
|---|---|
| 著者標目 | *J.N.Junk, Matthias author SpringerLink (Online service) |
| 出版者 | (Berlin, Heidelberg : Springer Berlin Heidelberg) |
| 出版年 | 2012 |
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| 巻次 | ISBN:9783642251351 |
|---|---|
| 大きさ | XVI, 212 p : online resource |
| 一般注記 | Electron Paramagnetic Resonance Theory -- The Functional Structure of Human Serum Albumin -- Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties -- Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels -- Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents -- Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities HTTP:URL=https://doi.org/10.1007/978-3-642-25135-1 |
| 件 名 | LCSH:Polymers LCSH:Spectroscopy LCSH:Chemistry, Physical organic FREE:Polymer Sciences FREE:Spectroscopy/Spectrometry FREE:Soft and Granular Matter, Complex Fluids and Microfluidics FREE:Physical Chemistry |
| 分 類 | LCC:QD380-388 DC23:541.2254 |
| 書誌ID | OB00007067 |
| ISBN | 9783642251351 |