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Epoxidations and Hydroperoxidations of α,β-Unsaturated Ketones : An Approach through Asymmetric Organocatalysis / by Corinna Reisinger
(Springer Theses, Recognizing Outstanding Ph.D. Research. ISSN:21905053)
| データ種別 | 電子ブック |
|---|---|
| 著者標目 | *Reisinger, Corinna author SpringerLink (Online service) |
| 出版情報 | 製作表示:Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer , 2012 |
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| 巻次 | ISBN:9783642281181 |
|---|---|
| 大きさ | XVI, 260 p : online resource |
| 一般注記 | Background -- Asymmetric Organocatalysis -- Catalytic Asymmetric Epoxidation of Electron-Deficient Olefins -- Synthesis and Relevance of 3-Hydroxy-1,2-dioxolanes and 1,2-Dioxolanes -- Objectives of this Ph.D. Work -- Results and Discussion -- Catalytic Asymmetric Epoxidation of Cyclic Enones -- Catalytic Asymmetric Epoxidation and Hydroperoxidation of Acyclic Enones -- Synthetic Transformations of Optically Active a,ß-Epoxy Ketones and 3-Hydroxy-1,2-dioxolanes -- Summary and Conclusions -- Mechanistic Considerations -- Preparation of Starting Materials -- Catalyst Synthesis -- Summary -- Outlook -- Experimental Part -- General Experimental Conditions -- Catalytic Asymmetric Epoxidation of Cyclic Enones -- Catalytic Asymmetric Hydroperoxidation and Epoxidation of Acyclic Enones -- Synthetic Transformations of Optically Active Products -- Preparation of Starting Materials -- Catalyst Synthesis Corinna Reisinger has developed a new organocatalytic asymmetric epoxidation of cyclic and acyclic α,β-unsaturated ketones. In this thesis, Corinna documents her methodology, using primary amine salts as catalysts, and hydrogen peroxide as an inexpensive and environmentally benign oxidant. She describes the unprecedented and powerful catalytic asymmetric hydroperoxidation of α,β-enones, a process which produces optically active five-membered cyclic peroxyhemiketals in a single operation. She also proves the versatility and synthetic value of the cyclic peroxyhemiketals by converting them into highly enantioenriched acyclic and cyclic aldol products. Currently, these cyclic aldol products are inaccessible by any other synthetic means. Furthermore, cyclic peroxyhemiketals are precursors to optically active 1,2-dioxolanes which are of biological relevance. This work is a breakthrough in the field of asymmetric epoxidation chemistry and outlines the most efficient method in the literature for generating highly enantioselective cyclic epoxyketones known to date HTTP:URL=https://doi.org/10.1007/978-3-642-28118-1 |
| 件 名 | LCSH:Chemistry, Organic LCSH:Catalysis LCSH:Chemical engineering FREE:Organic Chemistry FREE:Catalysis FREE:Industrial Chemistry/Chemical Engineering |
| 分 類 | LCC:QD415-436 DC23:547 |
| 書誌ID | OB00007298 |
| ISBN | 9783642281181 |