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Heteroaromatic Lipoxin A4 Analogues : Synthesis and Biological Evaluation / by Colm Duffy
(Springer Theses, Recognizing Outstanding Ph.D. Research. ISSN:21905053)
| データ種別 | 電子ブック |
|---|---|
| 著者標目 | *Duffy, Colm author SpringerLink (Online service) |
| 出版者 | (Berlin, Heidelberg : Springer Berlin Heidelberg) |
| 出版年 | 2012 |
書誌詳細を非表示
| 巻次 | ISBN:9783642246326 |
|---|---|
| 大きさ | XXII, 130 p : online resource |
| 一般注記 | Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation HTTP:URL=https://doi.org/10.1007/978-3-642-24632-6 |
| 件 名 | LCSH:Bioorganic chemistry LCSH:Biochemistry LCSH:Catalysis FREE:Bioorganic Chemistry FREE:Biochemistry, general FREE:Medicinal Chemistry FREE:Catalysis |
| 分 類 | LCC:QD241-441 DC23:547 |
| 書誌ID | OB00007252 |
| ISBN | 9783642246326 |