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NanoCellBiology of Secretion : Imaging Its Cellular and Molecular Underpinnings / by Bhanu P. Jena
(SpringerBriefs in Biological Imaging. ISSN:21933359)
| データ種別 | 電子ブック |
|---|---|
| 著者標目 | *Jena, Bhanu P author SpringerLink (Online service) |
| 出版者 | (Boston, MA : Springer US) |
| 出版年 | 2012 |
書誌詳細を非表示
| 巻次 | ISBN:9781461424383 |
|---|---|
| 大きさ | XII, 70 p. 38 illus., 33 illus. in color : online resource |
| 一般注記 | Understanding live cells at the single molecule level is the most important and single major challenge facing biology and medicine today. Over the past 15 years, there has been a renewed understanding of living cells at the molecular level. Atomic Force Microscopy, Laser Force Microscopy, single secretory vesicle patch clamp studies, highresolution electron microscopy, and x-ray diffraction, are some of the tools now being used to unravel the intricacies of a living cell at the molecular level. Opening with an explanation of Materials and Methods, NanoCellBiology then moves through discussions of porosome discovery, calcium and SNARE-induced fusion, and vesicle swelling before winding up in a final chapter of conclusions and future studies. Succinctly packaged as SpringerBrief, this book is a must for those studying or conducting research in cell biology, biochemistry or nanobiology/nanotechnology. This book will be invaluable to faculty & graduate students involved in Nano Courses; Cell Biology Courses; Biophysics Courses; and Biochemistry Courses as well as practicing Cell Biologists, Biochemists and BioPhysicists. Table of contetns: Introduction -- Materials & Methods -- Porosome Discovery -- Calcium & SNARE-Induced Membrane Fusion -- SNAREs need to reside in opposing membrane -- Membrane curvature dictates SNARE size -- Disassembly of membrane-associated SNARE complex -- CD spectroscopy confirm membrane requirement for t-/v-SNARE assembly -- SNAREs br ing opposing bilayers closer for calcium bridging -- Membrane lipids influence SNARE complex assembly-disassembly -- Vesicle swelling and content expulsion during cell secretion -- Secretory vesicle swelling is required for intravesicular content expulsion -- Molecular mechanism of secretory vesicle swelling -- Presence of beta receptors at the secretory vesicle membrane -- Conclusion and future studies Understanding live cells at the single molecule level is the most important and single major challenge facing biology and medicine today. Over the past 15 years, there has been a renewed understanding of living cells at the molecular level. Atomic Force Microscopy, Laser Force Microscopy, single secretory vesicle patch clamp studies, highresolution electron microscopy, and x-ray diffraction, are some of the tools now being used to unravel the intricacies of a living cell at the molecular level. Opening with an explanation of Materials and Methods, NanoCellBiology then moves through discussions of porosome discovery, calcium and SNARE-induced fusion, and vesicle swelling before winding up in a final chapter of conclusions and future studies. Succinctly packaged as SpringerBrief, this book is a must for those studying or conducting research in cell biology, biochemistry or nanobiology/nanotechnology. This book will be invaluable to faculty & graduate students involved in Nano Courses; Cell Biology Courses; Biophysics Courses; and Biochemistry Courses as well as practicing Cell Biologists, Biochemists and BioPhysicists HTTP:URL=http://dx.doi.org/10.1007/978-1-4614-2438-3 |
| 件 名 | LCSH:Life sciences LCSH:Cell biology LCSH:Microscopy LCSH:Nanoscale science LCSH:Nanoscience LCSH:Nanostructures FREE:Life Sciences FREE:Biological Microscopy FREE:Nanoscale Science and Technology FREE:Cell Biology |
| 分 類 | LCC:QH201-278.5 DC23:570.282 |
| 書誌ID | OB00006814 |
| ISBN | 9781461424383 |